Zonisamide

Zonisamide

1,2-Benzisoxazole-3-methanesulfonamide; Zonegran; ZNS; Zonisamidum; Methanesulfonamide derivative

CAS 68291-97-4

Chemical Formula C8H8N2O3S

Molecular Weight 212.23 g/mol

Zonisamide is a broad-spectrum anticonvulsant used in the treatment of partial seizures and certain neurological disorders. It belongs to the sulfonamide class and exhibits multiple mechanisms of action, including sodium and calcium channel blockade, carbonic anhydrase inhibition, and modulation of neurotransmitter release. Zonisamide is also under investigation for use in other CNS disorders such as Parkinson’s disease, bipolar disorder, and migraine prevention.

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Industrial Uses

1. Pharmaceuticals

  • Antiepileptic Drug (AED): Used as monotherapy or adjunct therapy for partial-onset seizures in adults and children. Reduces neuronal hyperexcitability by blocking voltage-dependent sodium and T-type calcium channels. Provides long half-life allowing once-daily dosing for better patient compliance.
  • Neurological Disorders: Studied and used off-label for Parkinson's disease to manage tremors and rigidity. Provides symptomatic relief in essential tremor and some cases of neuropathic pain. Being researched for use in bipolar disorder and schizophrenia adjunctive therapy.
  • Migraine and Weight Loss: Evaluated in clinical trials as a preventive treatment for migraines. Shows appetite-suppressing properties, sometimes used off-label in obesity management under supervision.

2. Animal Healthcare 

  • Canine Epilepsy Management: Used in veterinary neurology as a second-line treatment for seizures in dogs. Well-tolerated in long-term maintenance therapy for idiopathic epilepsy.
  • Exotic Animal Neurology: Occasionally prescribed for seizure control in cats, birds, and exotic pets under specialist care.

Specifications

Assay ≥ 99.0%
Appearance White to off-white crystalline powder
Odor Odorless
Boiling Point Not applicable
Melting Point 163 – 165 °C
Density Not available
Solubility Slightly soluble in water; soluble in DMSO and methanol
Viscosity Not applicable
Flash Point Not applicable

Hazard Symbols

Irritants/Sensitisers/Other Hazards

FAQs

1. What is the current price of Zonisamide in India?
The price of Zonisamide can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.6301 00 6301 directly for a customized quote tailored to your needs.

2. Where can I buy Zonisamide in India?
You can purchase Zonisamide from MULTICHEM, a leading exporter with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments global markets. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for Zonisamide?
Our minimum order quantity (MOQ) for Zonisamide is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 1 kg to 25 kg.

4. How can I ensure the quality of Zonisamide supplied by Multichem?
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.