Valproic acid

Valproic acid

2-Propylpentanoic Acid; Dipropylacetic Acid; VPA; Valproate (in salt form); DPA

CAS 99-66-1

Chemical Formula C₈H₁₆O₂

Molecular Weight 144.21 g/mol

Valproic Acid is a broad-spectrum anticonvulsant drug used for the treatment of epilepsy, bipolar disorder, and migraine prophylaxis. As a fatty acid derivative, it acts primarily by increasing GABA levels in the brain, stabilizing neuronal activity. Valproic Acid is listed in IP, BP, and USP pharmacopeias and is widely utilized in oral and injectable pharmaceutical formulations.

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Industrial Uses

1. Pharmaceuticals

  • Antiepileptic Drug (AED): Used as an API in tablets, capsules, syrups, and injectable formulations for treating generalized and partial seizures. Effective for tonic-clonic, absence, myoclonic, and mixed seizure types. Acts by enhancing GABA-mediated neurotransmission and stabilizing neuronal membranes.
  • Mood Stabilizer in Psychiatry: Prescribed for managing acute manic episodes in bipolar disorder. Helps in long-term mood stabilization and reducing recurrence of manic-depressive episodes. Used as monotherapy or adjunct to antipsychotics.
  • Migraine Prophylaxis: Included in prophylactic treatments for chronic and episodic migraines. Reduces migraine frequency and intensity by stabilizing cerebral excitability. Often preferred in patients with coexisting seizure disorders.
  • Pediatric Neurology Applications: Utilized in treatment of childhood epilepsy syndromes such as Lennox-Gastaut and absence epilepsy. Available in syrup or sprinkle capsule form for pediatric dosing flexibility. Titrated carefully to manage side effects in sensitive age groups.

Specifications

Assay ≥ 98.0%
Appearance Clear, colorless to slightly yellow liquid
Odor Slightly pungent or characteristic
Boiling Point 221–222 °C
Melting Point −50 °C
Density 0.905 g/cm³ at 20 °C
Solubility Miscible with ethanol and ether; slightly soluble in water
Viscosity ~6.5 cP at 20 °C
Flash Point 113 °C (closed cup)

Hazard Symbols

Irritants/Sensitisers/Other Hazards
Environmental Hazard

FAQs

1. What is the current price of Valproic acid in India?
The price of Valproic acid can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.6301 00 6301 directly for a customized quote tailored to your needs.

2. Where can I buy Valproic acid in India?
You can purchase Valproic acid from MULTICHEM, a leading exporter with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments global markets. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for Valproic acid?
Our minimum order quantity (MOQ) for Valproic acid is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 25 kg to 200 kg.

4. How can I ensure the quality of Valproic acid supplied by Multichem?
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.