Tetramethylammonium fluoride trihydrate

Tetramethylammonium fluoride trihydrate

Tetramethylammonium fluoridetrihydrate

CAS 111203-44-2

Chemical Formula C₄H₁₈FNO₃

Molecular Weight 175.13 g/mol

Tetramethylammonium fluoride trihydrate is an organic salt (CH3)4NF•3H2O used as a source of fluoride ions in organic synthesis. It is a white, crystalline solid that is highly soluble in polar solvents. Due to its hygroscopic nature, it is often encountered in its hydrated form. It's used in reactions like desilylation and as a phase transfer catalyst. 
 

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Industrial Uses

1. Pharmaceuticals

  • Fluoride Source in Organic Synthesis: TMAF•3H2O acts as a convenient source of fluoride ions, which are crucial for introducing fluorine into organic molecules.  This is particularly important in the synthesis of fluorinated pharmaceuticals, where fluorine can significantly alter a molecule's properties, such as its lipophilicity and metabolic stability.

2. Performance Chemicals

  • Desilylation Reactions: TMAF•3H2O is a useful reagent for removing silyl protecting groups from organic molecules. Silyl groups are often used to protect specific functional groups during multi-step synthesis, and TMAF•3H2O can selectively remove them when needed.
  • Fluorination: TMAF trihydrate is a key reagent in the synthesis of fluorinated compounds, including fluorinated aromatics and heteroarenes, which are building blocks for pharmaceuticals, agrochemicals, dyes, and advanced materials. 
  • Organic Synthesis: It is used in various organic reactions, including deprotonation of heteroarenes, halide-induced ring opening of aziridinium salts, and as a catalyst in palladium-catalyzed homocoupling reactions. 
  • Materials Science: TMAF trihydrate is employed in the synthesis of fluorinated poly(oxomolybdates) and as a reagent in cellulose acetylation.

Specifications

ASSAY 95%
Appearance White crystalline solid
Odor Odorless
Boiling Point Decomposes before boiling
Melting Point 62°C
Density 1.4 g/cm3
Solubility Highly soluble in water and polar solvents
Viscosity Not applicable
Flash Point Non-flammable

Hazard Symbols

Acute Toxicity
Irritants/Sensitisers/Other Hazards

FAQs

1. What is the current price of Tetramethylammonium fluoride trihydrate in India?
The price of Tetramethylammonium fluoride trihydrate can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.6301 00 6301 directly for a customized quote tailored to your needs.

2. Where can I buy Tetramethylammonium fluoride trihydrate in India?
You can purchase Tetramethylammonium fluoride trihydrate from MULTICHEM, a leading exporter with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments across global markets. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for Tetramethylammonium fluoride trihydrate? 
Our minimum order quantity (MOQ) for Tetramethylammonium fluoride trihydrate is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 25 kg to 250kg.

4. How can I ensure the quality of Tetramethylammonium fluoride trihydrate supplied by Multichem?
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.