Tenofovir disoproxil fumarate

Tenofovir disoproxil fumarate

TDF; Tenofovir DF; Viread; Tenofovir Disoproxil Hydrogen Fumarate; Tenofovir Fumarate

CAS 202138-50-9

Chemical Formula C₁₉H₃₀N₅O₁₀P•C₄H₄O₄

Molecular Weight 635.52 g/mol

Tenofovir disoproxil fumarate (TDF) is an antiretroviral medication belonging to the nucleotide reverse transcriptase inhibitor (NtRTI) class. It is widely used in the treatment and prevention of HIV-1 infection and chronic Hepatitis B. TDF is a prodrug that converts to Tenofovir in the body and inhibits viral replication by interfering with reverse transcriptase activity. It is commonly included in fixed-dose combination therapies and is a key drug in global antiretroviral programs.

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Industrial Uses

1. Pharmaceuticals

  • Hepatitis B Treatment: Used in monotherapy or combination regimens to manage chronic Hepatitis B virus (HBV) infection. Reduces viral load and improves liver function in patients with HBV. Helps prevent long-term liver damage such as cirrhosis or hepatocellular carcinoma.
  • Pre-Exposure Prophylaxis (PrEP): Combined with emtricitabine in oral dosage form to prevent HIV transmission in high-risk individuals. Plays a vital role in public health programs for HIV prevention and awareness. Recommended by WHO and CDC for at-risk populations including MSM and serodiscordant couples.
  • Pediatric HIV Treatment: Available in pediatric dispersible tablet and powder formulations. Ensures age-appropriate delivery of antiretroviral therapy to children living with HIV. Formulated in lower strengths for weight-based dosing in infants and adolescents.
  • Pharmaceutical R&D and Stability Testing: Studied in bioequivalence trials and formulation development for improved delivery (e.g., nanoformulations, long-acting injectable candidates). Evaluated for stability in tropical conditions under ICH guidelines. Included in research on drug resistance patterns and HIV pharmacogenomics.

Specifications

Assay ≥ 98.0%
Appearance White to off-white crystalline powder
Odor Odorless
Boiling Point Not applicable (decomposes)
Melting Point 115 – 125 °C
Density Not available
Solubility Freely soluble in water and methanol
Viscosity Not applicable (solid form)
Flash Point Not applicable

Hazard Symbols

Irritants/Sensitisers/Other Hazards

FAQs

1. What is the current price of Tenofovir disoproxil fumarate in India?
The price of Tenofovir disoproxil fumarate can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.6301 00 6301 directly for a customized quote tailored to your needs.

2. Where can I buy Tenofovir disoproxil fumarate in India?
You can purchase Tenofovir disoproxil fumarate from MULTICHEM, a leading exporter with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments global markets. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for Tenofovir disoproxil fumarate?
Our minimum order quantity (MOQ) for Tenofovir disoproxil fumarate is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 25 kg to 200 kg.

4. How can I ensure the quality of Tenofovir disoproxil fumarate supplied by Multichem?
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.