Nebivolol hydrochloride – IH

Nebivolol hydrochloride – IH

(±)-Nebivolol Hydrochloride; Bystolic HCl; Nebilet HCl; Nebivololum Hydrochloridum

CAS 152520-56-4

Chemical Formula C₂₂H₂₅F₂NO₄•HCl

Molecular Weight 441.90 g/mol

Nebivolol hydrochloride – IH is a cardioselective beta-blocker used primarily in the treatment of hypertension and heart failure. It is the hydrochloride salt form of nebivolol, offering improved stability and solubility. Known for its dual action—beta-1 receptor blockade and nitric oxide-mediated vasodilation—Nebivolol HCl is widely employed in the pharmaceutical industry for the formulation of cardiovascular drugs. The "IH" grade signifies that it is manufactured according to in-house specifications for regulated markets.

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Industrial Uses

1. Pharmaceuticals

  • Antihypertensive Formulations: Nebivolol HCl is widely used in the treatment of high blood pressure due to its cardioselective beta-1 blocking activity. It helps reduce heart rate and myocardial contractility, thus lowering blood pressure and cardiac workload. Often formulated into tablets for once-daily dosing due to its long half-life and dual-action mechanism.
  • Heart Failure Medications: Prescribed in chronic heart failure management, especially in patients with reduced ejection fraction. It improves cardiac output and symptoms by reducing heart strain and enhancing vasodilation. Its nitric oxide-potentiating effect offers added vascular benefits beyond traditional beta-blockers.
  • Combination Drug Products: Nebivolol HCl is also used in fixed-dose combinations with other antihypertensives like hydrochlorothiazide. These combinations improve therapeutic compliance in patients with comorbid hypertension. It is frequently developed in modified-release or bilayer tablet forms for enhanced control.

Specifications

Assay ≥ 98.5%
Appearance White to off-white crystalline powder
Odor Odorless
Boiling Point Not applicable (decomposes)
Melting Point 241–245 °C (with decomposition)
Density Not applicable
Solubility Freely soluble in methanol and water; sparingly soluble in ethanol
Viscosity Not applicable (solid)
Flash Point Not applicable

Hazard Symbols

Acute Toxicity
Irritants/Sensitisers/Other Hazards

FAQs

1. What is the current price of Nebivolol HCl – IH in India?
The price of Nebivolol HCl – IH can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.6301 00 6301 directly for a customized quote tailored to your needs.

2. Where can I buy Nebivolol HCl – IH in India?
You can purchase Nebivolol HCl – IH from MULTICHEM, a leading exporter with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments global markets. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for Nebivolol HCl – IH?
Our minimum order quantity (MOQ) for Nebivolol HCl – IH is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 1 kg to 25 kg.

4. How can I ensure the quality of Nebivolol HCl – IH supplied by Multichem?
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.