Losartan pottassium

Losartan pottassium

2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt; Cozaar (brand name); Losartan K

CAS 124750-99-8

Chemical Formula C₂₂H₂₂ClKN₆O

Molecular Weight 461.01 g/mol

Losartan Potassium is a prescription medication used to treat high blood pressure (hypertension) and to help protect the kidneys from damage due to diabetes. It belongs to a class of drugs called angiotensin II receptor blockers (ARBs), which work by relaxing blood vessels so blood can flow more easily. It is also used to reduce the risk of strokes in certain people with heart conditions.

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Industrial Uses

1. Pharmaceuticals

  • Antihypertensive agent: Losartan pottassium blocks angiotensin II type 1 (AT₁) receptors, preventing vasoconstriction and reducing aldosterone release. This lowers systemic vascular resistance and blood pressure, making it a first-line therapy for managing essential hypertension.
  • Heart failure adjunct therapy: Used in patients with left ventricular dysfunction or symptomatic heart failure, Losartan helps reduce preload and afterload, improving cardiac output and reducing hospitalization rates by attenuating harmful remodeling of heart muscle.
  • Renal protective agent in diabetic nephropathy: By lowering intraglomerular pressure and reducing proteinuria, Losartan slows progression of kidney disease in type 2 diabetic patients with hypertension. Its ability to reduce angiotensin II–mediated fibrosis helps preserve renal function.
  • Post-myocardial infarction therapy: Prescribed after an acute myocardial infarction in patients unable to tolerate ACE inhibitors, Losartan decreases mortality and reduces risk of heart failure by limiting adverse cardiac remodeling and improving hemodynamics.
  • Combination product component: Frequently combined with diuretics (e.g., hydrochlorothiazide) or calcium channel blockers in fixed-dose formulations to achieve synergistic blood pressure reduction and simplify dosing regimens, thereby improving patient adherence.

2. Animal Healthcare

  • Antihypertensive in small animals: Off-label in veterinary practice to manage systemic hypertension in dogs and cats, particularly in cases of chronic kidney disease or endocrine disorders. The mechanism—AT₁ receptor blockade—similarly reduces blood pressure and preserves renal function in animals.

Specifications

Assay ≥ 98% (typical pharmaceutical grade)
Appearance White to off-white crystalline powder
Odor Odorless
Boiling Point Not available (decomposes before boiling)
Melting Point 183–185 °C (lit.)
Density ~1.3 g/cm³ (approximate, not widely published)
Solubility Freely soluble in water; slightly soluble in methanol and ethanol
Viscosity Not applicable (solid compound)
Flash Point Not applicable (non-volatile solid; decomposes on heating)

Hazard Symbols

Irritants/Sensitisers/Other Hazards

FAQs

1. What is the current price of Losartan pottassium in India?
The price of Losartan pottassium can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.6301 00 6301 directly for a customized quote tailored to your needs.

2. Where can I buy Losartan pottassium in India?
You can purchase Losartan pottassium from MULTICHEM, a leading exporter with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments across global markets. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for Losartan Potassium?
Our minimum order quantity (MOQ) for Losartan pottassium is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 25 kg to 250kg.

4. How can I ensure the quality of Losartan pottassium supplied by Multichem?
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.