Chloramphenicol palmitate

Chloramphenicol palmitate

Chloramphenicol monopalmitate; Chloramphenicol palmitate ester; Palmitoyl chloramphenicol; D(-)-threo-1-p-nitrophenyl-2-dichloroacetamido-1,3-propanediol palmitate

CAS 530-43-8

Chemical Formula C₂₇H₄₂Cl₂N₂O₆

Molecular Weight 561.54 g/mol

Chloramphenicol palmitate is a prodrug form of chloramphenicol, designed to improve palatability and absorption, especially in oral pediatric formulations. It is an antibiotic used to treat serious bacterial infections such as typhoid fever, meningitis, and certain respiratory tract infections.

Industrial Uses

1. Pharmaceuticals

  • Prodrug for Oral Administration: Chloramphenicol palmitate is an inactive compound that converts into active chloramphenicol in the digestive system. This makes it ideal for oral use, especially in children who cannot tolerate the bitter taste of chloramphenicol base.
  • Taste-Masking Agent: Its palmitate ester form is virtually tasteless, which significantly improves patient compliance in pediatric populations compared to the bitter chloramphenicol base.
  • Broad-Spectrum Antibacterial Agent: It is effective against a wide range of Gram-positive and Gram-negative bacteria. It is used to treat severe infections like typhoid fever, meningitis, rickettsial diseases, and respiratory infections, especially when first-line antibiotics are unsuitable.
  • Alternative to Injection: In situations where injections are impractical or unavailable, especially in outpatient or rural settings, Chloramphenicol palmitate serves as an effective oral alternative.

2. Animal Healthcare 

  • Palatable Oral Antibiotic: Just like in human medicine, its tasteless formulation makes it easier to administer to animals, particularly young or small animals who are difficult to inject or dose with bitter medicines.
  • Systemic Antibacterial Agent for Animals: It is used to treat systemic bacterial infections in livestock, poultry, and companion animals, where other oral antibiotics may be rejected due to taste or compliance issues.
  • Non-Invasive Treatment Option: Reduces the need for injections, minimizing animal stress and the risk of injury during dosing. This improves overall animal welfare and treatment outcomes.

Specifications

Assay Typically ≥ 98% (varies by grade/pharmacopeia)
Appearance White to off-white crystalline powder
Odor Odorless or faint characteristic odor
Boiling Point Not applicable (decomposes before boiling)
Melting Point 85 – 89 °C
Density Not readily available; estimated ~1.1–1.2 g/cm³
Solubility Practically insoluble in water; soluble in chloroform, ethanol
Viscosity Not applicable (solid)
Flash Point Not available (non-volatile solid)

Hazard Symbols

Irritants/Sensitisers/Other Hazards

FAQs

1. What is the current price of Chloramphenicol palmitate in India?
The price of Chloramphenicol palmitate can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.6301 00 6301 directly for a customized quote tailored to your needs.

2. Where can I buy Chloramphenicol palmitate in India?
You can purchase Chloramphenicol palmitate from MULTICHEM, a leading exporter with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments across global markets. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for Chloramphenicol palmitate ?
Our minimum order quantity (MOQ) for Chloramphenicol palmitate is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 25 kg to 250kg.

4. How can I ensure the quality of Chloramphenicol palmitate supplied by Multichem?
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.