Bromoacetyl bromide

Bromoacetyl bromide

Bromoacetyl bromide; α-Bromoacetyl bromide; 2-Bromoacetyl bromide; Monobromoacetyl bromide

CAS 598-21-0

Chemical Formula C₂H₂Br₂O

Molecular Weight 201.84 g/mol

Bromoacetyl bromide is a specialized chemical intermediate used in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. It serves as a reagent for introducing bromoacetyl functional groups into target molecules.

Industrial Uses

1. Pharmaceuticals

  • Intermediate in Synthesis of Active Pharmaceutical Ingredients (APIs): Bromoacetyl bromide is used to prepare α-bromo carbonyl compounds, which serve as key electrophilic building blocks in drug synthesis. These compounds undergo further transformations into β-lactams, amino acid derivatives, and heterocyclic structures used in antibiotics, anticancer, and CNS drugs.
  • Reagent for Peptidomimetics and Enzyme Inhibitors: Due to its bifunctional nature, it is used in synthesizing enzyme-blocking agents that mimic peptide activity or interfere with active sites.

2. Agrochemicals

  • Building Block in Herbicides and Insecticides: Used in the synthesis of halogenated acyl derivatives and heterocyclic compounds for developing herbicides, fungicides, and larvicides. Its high reactivity enables the construction of complex molecules that interact with plant enzymes or insect nervous systems.
  • Modification of Bioactive Molecules: Enables the introduction of bromoacetyl moieties, enhancing the lipophilicity and membrane permeability of agrochemical agents.

3. Performance Chemicals

  • Versatile Intermediate for Heterocyclic Synthesis: Bromoacetyl bromide plays a vital role in the formation of 5-membered and 6-membered heterocycles, such as oxazoles, thiazoles, and isoxazoles, which are widely used as intermediates in multiple chemical sectors.
  • Source of Bromoacetyl Group: Acts as a key reactant in introducing bromoacetyl groups into amines, thiols, or alcohols, forming useful intermediates for further reaction in fine chemical synthesis.
  • Reagent in Structure-Activity Relationship (SAR) Studies: In medicinal and bioorganic chemistry research, Bromoacetyl bromide is often used to prepare probe molecules, enzyme inhibitors, or molecular linkers for studying biological interactions.
  • Synthesis of Reactive Intermediates: Used in developing novel organohalogen intermediates in research on asymmetric catalysis, bioorthogonal labeling, and drug delivery vehicles.

4. Polymers & Resins

  • Functional Monomer Precursor: Used in synthesizing reactive monomers or crosslinking agents that contain brominated side chains. These compounds are useful in developing flame-retardant polymers, photocurable resins, or reactive adhesives.
  • Surface Modification of Polymers: Bromoacetyl bromide is used to modify surfaces of polymer films or fibers by introducing reactive brominated groups that can undergo further chemical grafting or binding of active agents.

Specifications

Assay ≥ 97%
Appearance Colorless to pale yellow liquid
Odor Pungent, irritating odor
Boiling Point 145–147 °C
Melting Point -41 °C
Density 2.215 g/cm³ at 20 °C
Solubility Reacts with water; soluble in organic solvents
Viscosity Low viscosity (not commonly reported quantitatively)
Flash Point Flammable; Flash Point ~55 °C (estimated, closed cup)

Hazard Symbols

Corrosives
Acute Toxicity
Irritants/Sensitisers/Other Hazards

FAQs

1. What is the current price of Bromoacetyl bromide in India?
The price Bromoacetyl bromide can vary based on factors such as purity, quantity, etc. For the most accurate and competitive pricing, please contact us at +91.630 100 6301 directly for a customized quote tailored to your needs.

2. Where can I buy Bromoacetyl bromide in India?
You can purchase Bromoacetyl bromide from MULTICHEM, a leading exporter with a reputation for quality and reliability. We provide convenient options for bulk orders and direct shipments global markets. For more details on how to place an order, please visit our website or contact our sales team.

3. What is the minimum order quantity (MOQ) for Bromoacetyl bromide?
Our minimum order quantity (MOQ) Bromoacetyl bromide is designed to cater to both small-scale and large-scale needs. The MOQ depends on the packing size of the product which could range from 25 kg to 250kg.

4. How can I ensure the quality of Bromoacetyl bromide supplied by Multichem?                   
We adhere to stringent quality control processes to ensure that our products meet the highest standards of purity and effectiveness. They undergo rigorous testing and quality checks to guarantee that they comply with industry specifications. We provide a Certificate of Analysis (CoA) with every shipment to ensure transparency and quality assurance.