1. Performance Chemicals

• Creating Novel Structures: 2-Trifluoromethylphenothiazine is incorporated into larger molecules, often through reactions like click chemistry (e.g., Huisgen cycloaddition) to form 1,2,3-triazoles. 
• Modifying Properties: The trifluoromethyl group alters the electronic and steric properties of the molecule, affecting its lipophilicity, acidity, and hydrogen bonding capabilities. 
• Antitubercular Drug Design: It's been used in the synthesis of novel 2-(trifluoromethyl)phenothiazine-1,2,3-triazoles as potential antitubercular agents. 
• Antiproliferative Compounds: It's also used in the synthesis of compounds with potential antiproliferative activity against cancer cell lines. 
• Calmodulin Purification: 2-Trifluoromethyl-10-aminopropylphenothiazine (TAPP), a derivative of 2-trifluoromethylphenothiazine, is used in the purification of calmodulin, a calcium-binding protein.
• Building Block: 2-Trifluoromethyl Phenothiazine serves as a foundation for synthesizing other molecules with specific biological activities relevant to agriculture.

2. Pharmaceuticals

• Antipsychotic and Antidepressant Synthesis: The phenothiazine structure, including the trifluoromethyl-substituted version, is well-known for its antipsychotic properties. 2-(Trifluoromethyl)phenothiazine serves as a crucial intermediate in the synthesis of various antipsychotic and antidepressant medications.
• Antitubercular Agents: 2-(Trifluoromethyl)phenothiazine is used in the synthesis of antitubercular agents. Specifically, it has been hybridized with other compounds to create molecules with potential activity against Mycobacterium tuberculosis.